Asiti phosphatase maling: boikemisetso, decoding le sekhahla

Asiti phosphatase - e potlakisang tsebetso ea lik'hemik'hale hore eketsa li bole kapele 'ea limolek'hule' meleng. Boikemisetso ba boemong ba lona ka ho mali ke ntho ea bohlokoa bakeng sa diagnosing boemo ba bophelo bo botle. Ho na le mefuta e 'maloa ea phosphatases acid e, e leng abelana le ka tshebediso tsoanang, empa e fapana haholo ho tloha nngwe le e nngwe tse ling tse mabapi le lisele tse ea' mele ea, hlahang ho yona chromosomal, sebopeho.

dipalogotlhe

Tsamaisoa potlakisang tsebetso ea lik'hemik'hale ho libakeng asiti, ka hona ho lebitso. Asiti phosphatase fumanoa lisele tse sa tšoaneng le lisele tse ka sebakeng lysosomes le le ho feta. Palo kholo ka ho fetisisa a ikemiselitse ho ea tšoelesa ea senya tšoelesa, hammoho le ka lisele tsa makala tse latelang:

• sebete;
• spleen;
• lesapo moko;
• lisele tsa mali (erythrocytes, li-platelet, macrophages).

Ka bophelo bo botle phelang mosebetsi oa phosphatase acid e ke ho ena tlaase. Baemeli ba motona halofo boemong ba lona le na le prostatic phosphatase, le hore eo e timetsoa ka sebete 'me mali a lisele tse. The enzyme tsa 'mele e motšehali bōpeha ka ho feletseng timetsoa ke sebete le erythrocytes, li-platelet.

Lysosomal acid e phosphatase

E sebakeng lisele tse ngata. phoso lona ke autosomal recessive lefu, eo e nkoa e le ka lebaka la e hlophisitsweng, tshilong ya dijo pathological. Symptomatology ya lefu lena le bontša ka boeona e ka tsela e latelang:

• hill ho nyekoa ke pelo le ho hlatsa;
• bofokoli, ho lahleheloa ke bokgoni;
• theola khatello ea mali;
• bongoaneng - opisthotonus (sethoathoa tse etsahalang arching ea segopo morao, bakuli ba itšetleha ka holim 'a bethe ea feela molaleng le maoto);
• tsoa mali.

Ha boemo ba potlakisang tsebetso ea lik'hemik'hale e lekaneng feela lisele tse tšoeu tsa mali, bakuli ba hangata e utloa bohloko exacerbations ea tšoaetso ea sa foleng.

Prostatic acid e phosphatase

E ho nkoa e lesupa tsa dithulaganyo bakeng sa kankere ea tšoelesa ea senya. mofuta ona wa potlakisang tsebetso ea lik'hemik'hale ikemiselitse le ka peo lesupa mokelikeli ka liteko (peto). Asiti phosphatase o tsosoa, 'me matsatsi a seng makae ka mor'a ho buuoa ka ea tšoelesa ea senya tšoelesa kapa biopsy semelo sa.

Optimum ph pontshi bakeng sa tshebetso e nepahetseng ka potlakisang tsebetso ea lik'hemik'hale le - 4,6. Ketsahalo bonahala feela ka mor'a motho a fihla kena bonneng kapa bosaling.

Hona joale, qeto ea hore na boemo ba phosphatase prostatic ka lesupa kankere recedes ka semelo sa thahasello e ile ea eketseha ka ea tšoelesa ea senya-e itseng antigen, eo e khone ho netefatsa ho ba teng ha lefu lena ka mekhahlelo e pele ho moo ya ntshetsopele. Leha ho le joalo, ke litsupa tsa prostatic acid e phosphatase lona ke la bohlokoa boleloa esale pele ka ho boipheto tsa thulaganyou e bolaoa ke kankere ka mor'a ho buuoa ho tse khōlō ea tšoelesa ea senya ho tlosa.

and analysis le ho fumana hore na ho atleha ha kalafo ya nang kotsi prostatic hyperplasia le pathologies tse ling prostatic.

eritrotsitarnaja phosphatase

Ena ke polymorphic potlakisang tsebetso ea lik'hemik'hale hore hase feela ka lisele tse khubelu tsa mali, empa hape le ka liseleng tse ling tsa 'mele. The ph Optimum bakeng sa tšebetso ea oona e fapana ho tloha 5.2 ho 6.2.

Asiti mali phosphatase ka ho ikemisetsa ho hlakisa paternity. liforomo tse itseng tsa potlakisang tsebetso ea lik'hemik'hale le tse amanang le maemo a kang a latelang:

• predisposition liphatsa tsa lefutso ho khaello ea mali haemolytic;
• bolwetse, e tšoauoa ka tsoelo-pele ea haemolytic khaello ea mali ka morao ja legumes;
• khaello ea mali ka ho sebelisa lithethefatsi tse itseng kapa ho ntshetsa pele e tshwaetso se hlahang ho yona bongata ba kokwanahloko le baktheria.

Ho na le mefuta e meng ea erythrocyte acid e phosphatase amana ka ho toba ditlolo tse etsahalang ka bongoaneng.

Macrophage mofuta oa phosphatase acid e

The potlakisang tsebetso ea lik'hemik'hale e bohlokoa ka phumano ya lefu Gaucher. Sena ke lefu le futsitseng eo bontša bokella ka sebete, spleen, a liphio, boko, matšoafo glucocerebroside (dintho manyolo ho tloha sehlopha sa mafura). Lefu lena le e tsamaea le keketseho bohlokoa ka le boholo ba 'mele tse boletsoeng ka holimo, ho fokotseha bohale palo ea lisele tsohle mali, sethoathoa, sethoathoa spastic, kholofalo kelellong.

Macrophage acid e phosphatase o boetse o nkoa e le lesupa itseng bakeng sa kankere ea mali hairy seleng. lefu lena e tsamaea le ho hlahisa palo e khōlō ea potlakisang tsebetso ea lik'hemik'hale, e leng ikemiselitse ho mali.

phosphatase osteoclasts

Bitsoa lisele tse osteoclasts lesapo le boikarabelo ba ho timetsoa ha eona. Mohato ona ke ho nahanela bohlokoa ea khōlo ea lesapo le ntlafatsoa ha mohaho oo unit trust. Phahameng lebelo lesapo ke tahlehelo tsamaea le mafu a latelang:

• Paget ya lefu (pathological tswakana tloaelehile lesapo sebopeho le likarolo tsa lona);
• hypercalcemia tsa malignancy;
• hyperactivity ya thyroid le parathyroid litsoelesa ;
• postmenopause hammoho le osteoporosis.

Sephetho - fractures khafetsa le bo tsoelang pele e thinning mehaho masapo. Boikemisetso ba osteoclasts phosphatase acid e bontša maemo e phahameng ea enzyme ka semelo sa pathologies ka holimo.

Ho lokisetsa le ho khanna tlhathoba

Ditirisanommogo litsupa ikemiselitse ka maemo laboratoring. and analysis e lokela ho phethahatsoa ka mor'a matsatsi a 2 ho tloha mehleng ea mekgwatshebetso ya ho tse ling tekotshupo. Ha o batla ho hlahloba boemo ba prostatic acid e phosphatase, sena se lokela ho etsoa se pejana ho dihora tse 48 ka mor'a biopsy e, palpation ea tšoelesa ea senya e, senya catheterization. Tabeng bo fapaneng, liphello e ka 'na ea ba positives bohata.

Terata lintho tse bonahalang bakeng sa ho etsa lipatlisiso phethahatsoa ka mpeng letho. O ka noa metsi feela, ho noa tee, kofi, dijusi le lino tse ling tse e thibetsoe. Nakong ea letsatsi le, u lokela ho tela joala, mafura, lijana tsuba, hora e 1 pele ho and analysis - ho tloha ho tsuba. Fetileng halofo ea hora pele ja la lintho tse bonahalang e lokela ho etswa ka khutso feletseng maikutlong.

Bakeng sa fumanoe mali venous e sebediswa, e leng serum lona ho qoba hemolysis. Sephetho phuputso e entsoeng li tsejoa letsatsi le hlahlamang ka mor'a thuto.

The mokhoa sebediswa

Ho hlakisa boemo ba palo yohle acid e phosphatase sebediswa dithekeniki immunochemical le phumano chemiluminescent. Sebelisa substrates khethehileng hore kopana le potlakisang tsebetso ea lik'hemik'hale tse itseng. tsamaiso ea hona joale sebelisa luminol derivatives peroxidase hammoho le peroxide hydrogen tharollo. e le hantle ena e phaella ka ho re initiator (mohlala, n g-yodofenol) khonang ho eketsa luminescence ya tharollo makhetlo a likete tse 'maloa.

Ho na le litsamaiso tse ding hore sebelisa alkaline phosphatase le AMPPD substrate, ho etsa mokhoa tekotshupo le ho feta hlokolosi. Menyetla ya mokhoa ba ho ithuta botsitso ba reagents sebelisoa, ha ho na kotsi radiological. Mefokolo e thehiloeng ho rarahana ha tshebetso tekotshupo.

ntho e tloaelehileng

Kakaretso ea acid e phosphatase metsoako bontša U / L. entsprechen lona lumelleha fapana ho itšetlehile ka lilemo tsa le bong.

Normal prostatic litsupa acid e phosphatase - tlase ho 2.1 ka ng / ml tse. Lipalo kaofela holimo bontša phello e ntle ea phumano ea.

Ha boemo ba potlakisang tsebetso ea lik'hemik'hale le tse eketsehileng?

The maemo a tebileng ka ho fetisisa bakeng sa e mehato ditirisanommogo holimo ho tloaelehile:

• thrombocytopenia - e fokolitse palo ea lisele tsa mali le boikarabelo ba ho hoama lona;
• thromboembolism - blockage ea lumen ea ka sehloohong mothapo thrombus, detached ho tloha leboteng sejana, kapa embolus, ba leng maling;
• lefu haemolytic - lefu le tsamaea le timetsong ea ka tsa litonanahali tsa lisele tse khubelu tsa mali ho lokolla bokae bohlokoa tsa bilirubin ka maling;
• tsoelang pele Paget e lefu - lesapo bolwetse sethusathuto ka eo e imbalance pakeng tsa lesapo sebopeho le ho timetsoa ha ea likarolo e dumellana le bobeli;
• myeloma - hlahala thulaganyou e tlhaho, e leng e e-ba teng ka ho B-lymphocytes, ke eena ea ikarabellang bakeng sa tswakana lisele tse sireletsang;
• Niemann-nka lefu - lefa bolwetse tšoauoa ka metabolism phytoteratology mafura le bokella lipids ka makala a ka sehloohong (sebete, spleen, matšoafo, pelo, liphio);
• matsatsi a 'maloa ka mor'a ho buuoa ka ea tšoelesa ea senya tšoelesa le dinama tse nyenyane tse lona biopsy.

Asiti, alkaline phosphatase - sehlopha sa enzyme le boikarabelo ba ho e hlophisitsweng, bohlokoa ka 'mele. Ke ka thuso ea bona e simolohe liphetoho ea bohlokoa latellanang. Beha boemo ba enzyme o dumella nako ya ho hlahloba boteng ba bolwetse le loto e ho tšehetsa khalemelo ea ka ho eketsehileng phahameng boleng ba bophelo.