Lithethefatsi tsa Anticonvulsant Topamax: litaelo tsa tšebeliso

Koetliso ea "Topamax" ea lithethefatsi e bua ka sehlopha sa lithethefatsi tsa anticonvulsant, e leng sepheo sa eona se thibelang ho amohela li-receptor tsa sodium, ho tlosa li-spasms le ho felisa thabo ea methapo. Motheo oa lithethefatsi ena ke keketseho mosebetsing oa γ-aminobutyric acid le ho thibela mosebetsi oa carbonic anhydrase isoenzymes. Ho phaella moo, "Topamax" ea "antiamapileptic" (taelo, e kenyelletsitsoeng ho eona, e netefatsa) e etsa hore ho be le kutloisiso ea mekhoa ea GABA-receptors. Ka lebaka la ho sebelisa meriana ena meleng oa mokuli, ho na le ho hlakileng ho khahlanong le ho ruruha, antispasmodic le analgesic effect.

Topamax e hlahisoa (taeo e boetse e bontšoa) ka mofuta oa li-capsules tsa gelatin, tse nang le topiramate ka boholo ba limilimithara tse mashome a mabeli a metso e mehlano kapa tse mashome a mahlano e le karolo e ka sehloohong. Lisebelisoa tse thusang ke cellulose, acetate, granules le tsoekere. Sebopeho sa khetla ea capsule e kenyelletsa lintho tse kang sodium lauryl sulfate, gelatin, sorbitan monolaurate, metsi, titanium dioxide le enke.

Ho khetha meriana e nang le likokoana-hloko "Topamax" taelo ea tšebeliso e fana ka keletso ea haholo-holo bakeng sa phekolo ea bakuli ba nang le lefu la sethoathoa kapa Lennox-Gastaut. Ho phaella moo, lingaka li ikemiselitse ho fana ka pheko ena ho batho ba nang le migraine, tonic-clonic, khethollo kapa myoclonic seizures. Ho phaella moo, meriana ena ea antiepileptic e sebetsana hantle le ho ba sieo 'me e khona ho felisa mesifa ea mesifa ka nako e khutšoanyane.

Nka li-capsules Topamax e thibela batho ba nang le hypersensitivity ho holimo kapa ho ba le tšoaetso ea letho ho likarolo tse ling tse nang le lihlooho. Hape ha ho kgothaletswe hore o ngotse anticonvulsant ho basali ba jereng lesea. Lethathamo la li-contraindication tse thata li kenyelletsa nako ea lactation, le lilemo tse ka bang peli. Ka tlhokomelo e fetisisang, batho ba nang le nephrourolysis, ba se nang pheko kapa ba se nang pheko ba lokela ho noa meriana ena.

Ho qoba ho sebelisa lithethefatsi tsena tsa antiepileptic ho lokela ho ba le bakuli ba nang le hypercalciuria.

Ha e le ka liphello tse bohloko tse ka bakoang ke tšebeliso ea Topamax, pele ho tsohle, ho hlokahala hore ho khetholle maemo a kang ho ba le botenya, khathatso ea tlhokomelo, paresthesia, ho se thahaselle, mokhathala, ho sithabela le ho otsela. Ho phaella moo, ho ka 'na ha fokotseha takatsong ea takatso ea lijo, bothata, ho tseba lintho tse ling, hypoesthesia, dysarthria, ho thothomela, ho sithabela le ho ba le maikutlo a maikutlo. Ho khathatseha ka mpeng, gastritis, molomo o omeletseng, masapo a tsoa mali, glossodynia le ho patoa ho ka boela ha etsahala ho batho ba nkang li-capsules tsa Topamax. Lipilisi tsena li ka baka mesifa ea mesifa, tsoelo-pele ea myalgia kapa arthralgia, feberu le ho hema ka thata.