"Monosan": buka ea litaelo, litlhaloso, li-analogs

Bakeng sa kopano ea "Monosan" e lokiselitsoeng eng le ka tekanyo efe? Litaelo tsa tšebeliso ea sena vasodilator li hlalositsoe ka ho qaqileng ka thepa ea sehlooho sena. Hape ho eona ho tšoana le lithethefatsi, libopeho tsa eona, liketso tsa meriana, li-contraindications, liphello tse bohloko, joalo-joalo.

Foromo, liphutheloana, boqapi

Ke lisebelisoa life tse kenyelletsoeng lithethefatsi "Monosan"? Taelo e re karolo e sebetsang ea lithethefatsi ena ke isosorbide-5-mononitrate. Meriana e kenyelletsa likarolo tse joalo tse thusang joaloka lactose ea talc granular, magnesium stearate, celcrylose microcrystalline le starch ea poone.

Bahlahisi ba hlahisa lithethefatsi "Monosan" ka mofuta ofe? Taelo ea tšebeliso e bolela hore meriana ena e ka rekoa feela ka matlapa. Li na le 'mala o mosoeu' me li pota-potile. Ka lehlakoreng le leng la pilisi ho na le kotsi.

Moriana oo o tletse blisters, e leng paketeng ea lik'harete.

Likarolo tsa tlhaho

Lithethefatsi tsa "Monosan" li sebetsa joang? Litaelo tsa tšebeliso li bontša hore lithethefatsi ena ke vasodilator ea sephahla, e amang haholo lijana tsa majoe.

Meriana e kgona ho kgothaletsa tlhahiso ea phetoho e joalo ea boikhathollo ea endothelial e kang nitric oxide e nang le li-vascular endothelium. Ka lebaka la tšusumetso ena, ho sebelisoa guanylate cyclase (enzyme ea intracellular) ho etsahala, e leng eona feela e lebisang hoketsekong ea mokena-lipakeng oa vasodilating - cyclic guanosine monophosphate.

Ka mor'a ho noa lithethefatsi, tlhokahalo ea lisele tsa motlakase ho oksijene e fokotseha. Sena se bakoa ke ho fokotseha ha litekanyetso tsa poso le pelehi.

Hape, ketso e hlakileng ea ho itšireletsa ea lithethefatsi e ngotsoe ke litsebi.

Liphello tsa lithethefatsi

Ke lisebelisoa life tse ling tseo meriana ea "Monosan" e nang le eona? Tšebeliso ea lithethefatsi ena e thusa ho fokotsa phallo ea mali ho ea ho atrium e nepahetseng, e leng ho fokotsang khatello e kholo ho potoloha ho fokolang le ho fokotsa matla a matšoao a matšoao a edema ea edema.

Hape hoa lokela ho hlokomeloa hore tlas'a tšusumetso ea "Monosan" libakeng tse nang le tšollo ea mali e senyehileng ho na le ts'ebetsong ea phallo ea mali ea mali

Ho fapana le bothata ba ho noa lithethefatsi ho batho ba nang le lefu la pelo le angchemic, ho hanela likhatello leha e le life tsa 'mele ho eketseha haholo. Ho phaella moo, moemeli ea ntseng a hlahlojoa o khona ho theola lik'hamphani tsa intra-flatlet synthesis ea Tx le ho thibela platelet aggregation.

Pharmacokinetic properties

Mofuta o mong oa "Monosan" o hokae, o abuoa le o sebelisoa? Thupelo ea tšebeliso e bolela hore ntho e sebetsang ea moriana e potlakile ebile e kenngoa ka ho feletseng ho tloha pampiring ea lijo. Ka mor'a ho noa pilisi, phello ea antianginal e hlokomeloa kamora 'metsotso e 30-45' me e nka lihora tse 10.

Ho ea ka litsebi, lithethefatsi "Monosan" e na le litekanyetso tse phahameng tsa bioavailability (hoo e ka bang 99-100%). Sena se bakoa ke ho haelloa ke pase ea pele ea lithethefatsi ka mokhoa oa hepatic.

Bophelo ba halofo ea moriana ke metsotso e 60. Ho kenella ha lithethefatsi maling ho fapana haholo ebile ho itšetlehile ka litšobotsi tsa motho ka mong.

Metabolism ea ntho e sebetsang ea lithethefatsi e etsoa sebeteng. Ka lebaka la mekhoa ea metsoako, likarolo tse tharo li thehoa: isosorbide le tse peli tsa glucuronides tsa isosorbide-5-mononitrate.

Bophelo ba halofo ea moriana ke lihora tse 4-5. Ka nako e tsoanang, 2,2% e phunyeletsoa ka mokhoa oa renal, le 97.8% - ka mokhoa oa metabolite ea glucuronic.

Lipontšo tsa tšebeliso

Ke maemo afe ao Monosan a khethiloeng ho 'ona? Tšebeliso ea lithethefatsi ena e atleha ka ho fetisisa maemong a latelang:

• Phekolo ea mokuli ea mali, pelo ea pulmone;
• Ho hloleha ha pelo ea foromo e sa foleng;
• Thibelo ea litlhaselo tsa angina ho batho ba nang le lefu la pelo ea kelello.

Litemoso tsa tšebeliso

Ke maemo afe a ke keng a sebelisa "Monosan"? Li-analogues le litsela tse boletsoeng ka holimo li hanetsoe ho nka:

• Ho oa ha pelo;
• Fetoha boemo;
• Arterial hypovolemia le hypotension ea arterial;
• Li-cardiac tamponade ;
• Ho hlōleha ha ventricular le tlase diastolic khatello ea mali;
• Edema ea chefo ea mali;
• Mokhoa o motle oa ho phalla ha lifofane tsa moricardial (ka lebitso le bitsoang hypotension);
• Mofuta oa glaucoma;
• Ho fepa;
• Maloetse a etsang hore ho be le khatello ea khatello ea kelello;
• Hypersensitivity ka bomong;
• Bongoaneng le bocha (pele e se e le motho e moholo).

Hape hoa lokela ho hlokomeloa hore moemeli ea kenngoa potso o na le melaetsa e fapaneng. Tsena li kenyeletsa tse latelang:

• Stralosis ea Mitral ;
• Khatello ea likhahla;
• Botsofali;
• Mathata a Orthostatic ea tsamaiso ea mesifa;
• Ho hloleha ha tsamaiso ea renal;
• Hypertrophic cardiomyopathy;
• Thyrotoxicosis;
• Ho se sebetse hantle ;
• Stenosis ea Aortic;
• Ho kula ha mali.

Ho lokisetsa "Monosan": litaelo tsa tšebeliso

Lebitso la INN (lebitso la machaba le se nang matlo) la meriana ena le utloahala joaloka "isosorbide mononitrate". Meriana ena e behiloe molomong feela. Ho ea ka litaelo, e lokela ho metsoa ka ho feletseng le ho hlatsuoa ka metsi.

Etsa hore pilisi e be ngaka feela. Ka nako e ts'oanang, o tlameha ho lekanya ho teba ha lefu la motheo la mokuli oa hae.

Kalafo "Monosan" e qala ka ho nka 10-20 mg ea lithethefatsi ka makhetlo a mararo ka letsatsi. Ka matsatsi a 3-4 a phekolo, molao oa tekanyo o lokela ho fetoloa. Haeba ho hlokahala, palo ea lithethefatsi e eketsehile ho fihlela ho 20-40 mg 'me e nkoa habeli ka letsatsi.

Matšoao a ho Overdose

Ke matšoao afe a ho feteletsa metsi ho ka 'nang ha etsahala ho mokuli ka lijo tse sa nepahalang tsa Monosan? Litaelo tsa tšebeliso li bontša matšoao a latelang: ho oa, syncope, lefu la letšollo, mokokotlo, hyperpnoea, reddening ea letlalo, methemoglobinemia, dyspnoea, tachycardia ea mokokotlo oa mokokotlo, hlooho ea hlooho, hyperthermia, thibelo, bofokoli, khatello e sa tsitsang ea khatello ea maikutlo, khatello ea maikutlo, Ho kula, ho nyeheloa ke pelo, ho khaola, ho eketseha ho fufuleloa, ho hlatsa.

Ha e le phekolo ea maemo a joalo, ho sebelisoa mekhoa e sebelisoang bakeng sa ho hlaphoheloa ka mpeng, 'me likarolo tsa enterosorbent li boetse li laeloa.

Litla-morao

Na lithethefatsi tsa Monosan li baka likarabo tse sa batleheng? Litaelo tsa tšebeliso (litšoantšo tsa meriana li bontšitsoe ka tlaase) li bolela hore moriana o joalo o ka baka litla-morao tse ngata. A re boleleng tse ling tsa tsona:

• Ho otla;
• Ho utloahala ho utloahala ka leleme;
• Molomo o omileng;
• Nausea;
• Ho utloa mocheso;
• Tachycardia;
• Nitrate hlooho;
• Hyeremia ea letlalo ;
• Ho na le botsoa;
• Ho thehiloe ho fokotseha ha khatello ea mali;
• Litlhaselo tse ngata tsa anginal;
• Ho oa ha Orthostatic ;
• Ho otsela ho eketsehileng;
• Ho lieha ha lintho tsa kelello le likoloi;
• Matšoenyeho;
• Pono e fosahetseng;
• Ho thehoa ha mamello;
• Litlama tse khethehileng tsa letlalo;
• Dermatitis e feteletseng.

Mantsoe a lithethefatsi le theko ea lona

Nka sebelisa meriana ea "Monosan" joang? Ho na le lipapiso tsa meriana ena pharmacy e 'ngoe le e' ngoe. Har'a tse atlehang haholo ke Monochinkwe, Isoket, Kardiket, Efoks, Pektrol.

Ha e le theko ea lithethefatsi, ha e phahame haholo. U ka reka meriana metseng ea Serussia ka li-ruble tse 100 feela (lipilisi tse 30).

Tlhahlobo ea Mamello

Tokisetso eo re e nahanang e na le litlhaloso tse ngata tse ntle. Bakuli ba bolela hore e iponahatsa e le pheko e sebetsang haholo bakeng sa khatello ea kelello ea pulmonary le ho hloleha ha pelo ho sa foleng. Leha ho le joalo, ho lokela ho hlokomeloa hore ho fumana phekolo e phahameng ea phekolo, moriana ona o tlameha ho kopanngoa le lithethefatsi tse ling. Ho etsa sena, o lokela ho ikopanya le ngaka kamehla.

Ke boetse ke batla ho hlokomela hore bakuli ba bangata ba khahloa ke theko ea meriana e hlahisoang. Joalokaha ho boletsoe ka holimo, bakeng sa matlapa a 30 u tla tlameha ho fana ka li-ruble tse 100 feela tsa Russia.

Motho a ke ke a thusa ho bolela hore moriana ona o atisa ho sala ka maikutlo a fosahetseng. Maemong a mangata, li kopantsoe le litla-morao tse sa tšoaneng. Ka tsela, ha ba tsoa ho noa lithethefatsi, ho molemo ho hana le ho e nkela sebaka ka tsela e sireletsehileng. Joang, u ka bolella feela setsebi sa phihlelo.