Lefu le autoimmune ke thrombocytopenic purpura

Ka lekhetlo la pele e autoimmune thrombocytopenic purpura, o ne a ile a hlalosa ka 1735 Verlgofa ba hlokomela le lefu lena ka ngoanana lilemo tse leshome '. Jwale tlasa foromo ena lebitso kopantswe autoimmune thrombocytopenia, sesosa autoaggression ka eo a hloleha. Ba hlaha hemorrhagic diathesis le khaello thōko sa liplatelete. Abelwang karolo ya a hlobaetsang le a sa foleng mofuta o mong oa lefu lena.

lisosa tsa

Hlobaetsang thrombocytopenic purpura utloa bohloko hangata bana ba lilemo li lilemo tse 2 ho ea ho 9. Thrombocytopenic purpura ka bana e tšoauoa ka ho qala ka tšohanyetso 'me a hlaphoheloe ka potlako. Ntshetsopeleng ya liponahatso tsa tleleniki hangata e khothalletsa batho hore tshwaetso bongata ba kokwanahloko ea ka holimo ho hema pampitšana kapa pampitšana tshilong ya dijo. Ka 10% ea maemo a ho lefu amanang le tsoelo-pele ea varicella virus, Epstein-Barr virus, entoa, BCG immunotherapy. itseng timetsong Platelet e loketseng ho ka karabelo boitshireletso ba phelang ho ena le ketso ea kokoana-hloko.

liforomo foleng la thrombocytopenia hlolang ka nako e dikgwedi tse fetang 6 e bitsoa idiopathic thrombocytopenic purpura. Sesosa sa lefu lena le ke e sa tsejoeng. Thrombocytopenic purpura hangata e qala lilemong tsa bocha, kena bonneng kapa bosaling. More atile basali.

Clinical liponahatso hlahella butle-butle. Tšoauoa ka chronically-iphetang kapa nako e telele tsela ea lefu lena. Pathogenetic motheong oa lefu e matlafatsa le ho potlakisa platelet felisoeng ha ke autoantibodies khahlanong le bona.

setshwantsho ea tleleniki

Ka letlalo la bakuli ba matšoao a microcirculatory mali mofuta ka punctate petechial lekhopho nyane subcutaneous hematoma, purpura ka mucosa molomo. Tšoauoa ka tsoa mali ba lera la mucous nko, marenene. Liphetoho letlalong, hangata e ba sebakeng holim'a pel'a lipheletsong kutu, e ka holimo ka tlaase le e. Ka tloaelo ho ne ho thehoa hemorrhage kgolo libakeng ka ente. Ka linako tse ling ho ka ba le ho tsoa mali ka sclera le ho retina, tsoa mali ho tswa ho pampitšana tshilong ya dijo. Ho basali ba, ho na le hemorrhages ka mae a bomme ka. Ka mefuta e mpe ea mali ke lefu renal ka 'na etsahala.

purpura Thrombocytopenic ho ka etsa hore mathata a kotsi tse kang hemorrhage bokong le subarachnoid hemorrhage. Bath e-positive cuff teko-Konchalovsky tiller-LEED: sebopeho sa hemorrhages libakeng letlalo la compression. Lisele tsa mmele nodes, sebete le spleen ha atolosoa.

tlhathoba

The tšobotsi e ka sehloohong ea laboratoring ke ho fokotsa palo ea li-platelet. mali hoama nako e sa tlōla. Heparin lero la mali e se e eketsehile. Maemong a mangata, e behilweng ke keketseho ea immunoglobulin G -platelet. Mora mali bohlokoa hlalosoa hlobaetsang hemorrhagic khaello ea mali.

kalafo

Ha fumanoa hore o tšoeroe ka thrombocytopenic purpura, bakuli ba qala kalafo ka corticosteroids. Nakong ea kalafo, bakuli ba a hlokomela keketseho e tsitsitseng ka platelet le bala ho fihlela ho leballa motho ka ho feletseng. Ho haella ha e sebetsa corticosteroids le immunomodulators balletsweng delagil. Le katleho ha ea phekolo mekhoa e tloaetsoeng ka hare ho likhoeli tse 6 ho kgothaletsa ho etsa splenectomy.

E mong sebakeng sa phekolo - tsamaiso ya tekanyetso e phahameng ea immunoglobulin bakeng intravenous ente bakeng sa matsatsi a 5. litokisetso tsena inactivate lisireletsi hore tlama le ho tlosa bongata ba kokwanahloko, baktheria le tse ling tse antigens.

Ka 80-90% ea bakuli ka hlaphoheloa itlelang feela le hlaha ka hare ho likhoeli tse 1-4. Maemong a mang, thrombocytopenic purpura ka nka ho fihlela ho likhoeli tse 12. Lefu lena le ke chronically relapsing: tsoa mali linako ngoe le linako tsa ho leballa motho.