Collagen - ke eng? Le matšoao, phumano le kalafo ea mafu a

phumano ya "collagen" le atisa ho fumanoa ka moriana ea kajeno. ha e le eng? Ha e le hantle lentsoe lena le tlisa hammoho e mengata e mafu a fapaneng hore na ntho e 'ngoe e tšoanang - liphetoho dinama tse nyenyane tse connective, tse kang diso collagen fibrinoid.

Ke 'nete hore bakuli ba na le boloetse ba "systemic connective dinama tse nyenyane tse" lehlanya ka tlala tšabo e. Kahoo pele lokela ho ithuta ho eketsehileng ka mafu tsena le lintho tse khethollang bona. Eo mafu a kenyelelitsoe sehlopha sa dinama tse nyenyane tse connective? ke bakang bona eng? Seo matšoao a lokela ho lefa a lebisa tlhokomelo ho? Nka tlosa mafu collagen ho sa feleng? Ke hobane'ng ha ho weather forecasts fa lingaka? Likarabo tsa lipotso tsena li batla e ngata batho.

Collagen: ke eng?

dinama tse nyenyane tse Connective o tsejoa ho ba mosa le ea ho haha lintho tse bonahalang bakeng sa 'mele. Ka mohlala, ho e bopa masapo le letlalo motho, mali a sejana se mabota, e stroma tsa litho tsa ka hare, 'me hape o tlatsa interstices le pakeng tsa mehaho e fapaneng. Ho lesela lena, 'me tse fetang halofo ea boima ba' mele ea batho. likarolo Connective phetha mesebetsi 'maloa bohlokoa, ho akarelletsa le trophic, sireletsang, mehaho, tšehetso le polasetiki. Ke connective mafu dinama tse nyenyane tse ho kopantswe, poleloana e reng "collagen".

ha e le eng? This sehlopha sa pathologies hore na le litšobotsi tse neng li tloaelehile 'me mochine oa ntlafatso. Lefu lena le hlaha ka semelo sa ditlolo tsa homeostasis boitshireletso le di tsamaisana le liphetoho tse fibrinoid collagen.

Types of mafu collagen

moriana morao-rao tsebahalang tse fapa-fapaneng collagen. tlhophiso bona e thehiloe ka tšimoloho ea lefu lena. Ka mohlala, diffuse connective dinama tse nyenyane tse lefu ka 'na ba congenital. sehlopha sena se akarelletsa Stickler syndrome, le Marfan le mucopolysaccharidoses le osteogenesis imperfecta. Matšoao a bona ba atisa ho hlaha esita le ka ho utero.

Ho na le boetse ho na le mafu a fumana hore ka bontša ka mor'a tsoalo - ka linako tse ling bongoaneng kapa lilemo tsa bocha, 'me ka linako tse ling esita le ka batho ba baholo. Sena pathologies sehlopha kenyeletsa systemic vasculitis, skerodermiyu, ramatiki, rheumatism, eozinovilny fasciitis, periarteritis nodular, 'me ba bang ba bangata.

Lisosa tsa sehlooho tsa lefu

Maemong a lefu congenital li amahanngoa le mafu a liphatsa tsa lefutso le metabolism tsa collagen sebopeho. Ha e le diforomo tsa fumana lefu lena, ho na le lebaka ka ba tse fapa-fapaneng haholo, 'me ho ithuta ka mochine oa bolwetse ntse ke tsentswe.

Bo-rasaense ba na le tšekamelo ea ho lumela hore e itseng liphatseng tsa lefutso le lefa o hoo e batlang e mong le e mong joalo. Empa lefu lena le se ka mo lakalisa mabaka a 'maloa. Mohlala, hangata tsosang ka ho kenella ka hare ka 'mele oa tšoaetso ea bongata ba kokwanahloko le baktheria, ho akarelletsa le likokoana-hloko mumps, herpes, rubella, maselese, joalo-joalo D..

bakang ka 'na ba lelemela hormonal hore etsahala nakong kena bonneng kapa bosaling, ho ima le menopause, ho ntša mpa le joalo-joalo. D. Ho boetse ho na le mabaka a mang tse bakang lefu lena le hlaha. Collagen ka tseko ke khatello ea kelello le matla, ho sithabela, tsamaiso ea lithethefatsi, undercooling matla, insolation. Ka linako tse ling boloetse bona develops ka mor'a ente.

The pathogenesis lefu lena

Ho sa tsotellehe ho se tšoane tsa sehlopha sena sa mafu a, ka hoo e ka bang mong le e mong joalo, ka bolwetse develops ka leqheka la tšoanang. Ha liphello tsa ntlha e itseng, nahanela ya boitshireletso ba mmele, ho fellang ka sebopeho sa mehahong e itseng protheine, tse ka nako eo beha ka lera la serous le mokelikeling, lera la lijana. Ho ba teng ha mehahong boitshireletso qholotsa e ruruha alejiki ya lisele tse sa. Kahoo, sesole sa 'mele oa motho o qala ho hlasela connective tsa lona dinama tse nyenyane tse.

Khahlanong le semelo sa dithulaganyo tse ka holimo-o ile a hlalosa a lemohiloeng liphetoho pathological tsa lisele. Ya e le hantle, e mong le e mofuta wa lefu connective dinama tse nyenyane tse nang le makgetha a ho itseng. Ka mohlala, ka scleroderma autoimmune ruruha ama letlalo dinama tse nyenyane tse 'me subcutaneous dinama tse nyenyane tse,' me tšoauoa ka sa fetola periarthritis lijana nodosa.

Collagen: Foto le kakaretso ea tleleniki setshwantsho

ke eng setshwantsho ea tleleniki? Seo matšoao a tsamaea le collagen? Le matšoao, ya e le hantle, e tla fapana ho ea ka mefuta e fapaneng ya lefu le sebaka ea ho a hlabang. Leha ho le joalo, tse ling tse neng li tloaelehile ka ho tsejoa.

Mokuli o na le leqoophe feberu ho fihlela ho likhato 38. Bakuli ba tletleba ba chills le ho fufuleloa ka tsela e feteletseng. Ho na le bofokoli bo itseng le fokotseha tshebetso. Hoo e batlang e leha e le efe collagenosis foromo develops e kopanetsoeng 'me mesifa lefu, e leng e tšoauoa ka lenonyello le bohloko, myalgia le arthralgia. liphetoho ka linako tse ling alejiki, ponahalo ea letlalo lekhopho, bohloko mpeng, dyspepsia.

Periarteritis nodosa le litšobotsi tsa lona

Collagen sa tšoaneng tsa tlhaho, kahoo e Ke habohlokoa ho nahana ka ho fetisisa tloaelehileng le le boima mefuta e sa tsoaneng. Periarteritis nodosa e tšoauoa ka diso tsa le dikarolo tsohle tse tharo tsa leboteng sejana. Tsela hlabang ameha hoo e batlang e lijana tsohle tsa 'mele.

Matšoao a itšetleha ka mofuta ofe methapo le methapong ne ba makaletse. Ha ho tluoa tabeng ea lijana tsa liphio, bakuli tsebiso pele bohloko, pherekano ea outflow ea moroto. O ile a re kgatelelo ya madi le tsoelang pele ho hloleha renal. Ha ho ruruha ha marako a methapo ea mali bokong ka mamello hlahisa mafu a tse fapa-fapaneng a kelello. A kotara ea bakuli ba periarthritis nodular hlokomela asma.

Systemic lupus erythematosus

Systemic lupus erythematosus - haholo systemic connective dinama tse nyenyane tse. ha e le eng? Ena lefu, e leng e tsamaea le diso tsa hoo e batlang e tsamaiso ea tsohle lekala. Hlaha ka letlalo bo bofubelu ruruha foci (ka sefahleho, ba na le sebaka se khetholloe haholo ka marameng le nko e tšoana le mapheo a serurubele a).

Ho na le ho felloa ke moriri le manala, ho lera la mucous hlaha seso le khoholeho ea mobu. Tsela hlabang akarelletsa manonyeletso nyenyane. Lefu lena le e tsamaea le mafu a ea tsamaiso ea pelo le methapo le ho hema. Renal malwetse a hlokomela 'me ponahalo ea matšoao a methapo ea kutlo.

systemic scleroderma

Scleroderma - lefu mong autoimmune oo tshebetso a hlabang ama letlalo, subcutaneous dinama tse nyenyane tse, methapo ea mali pheriferale, manonyello le mesifa. Tabeng ena, matšoao a totobetseng ka ho fetisisa ke liphetoho letlalo feela. Ntlha ea pele, ho na le e ho ruruha ea letlalo. The dermis fetoha lerootho kapa, ho seng jwalo, e khubelu. Ka Bohato ba bobeli ho ruruha ha lefu lena le fetoha le letšo-letšo haholo, le boreleli letlalo la mamello le ho omileng adhesions thehoa le lisele tse ka sehloohong.

Mohato oa boraro e tsamaea le ho felloa ke matla tsa letlalo 'me lisele tse subcutaneous. phelang batho ba ba le mamello e khathetse, menoana butle-butle a holofala, sefahleho nka sebōpeho sa maske e loketseng ho nyamela ha sefahleho.

Tsela tekotshupo

Tsela ea ho hlahloba lefu le dinama tse nyenyane tse? Ho hlōloa ha 'mele e sa tšoaneng tsamaea le ho hlaha ha matšoao a itseng,' me eo hulelang tlhokomelo ea ngaka e ka buisana le mamello le anamnesis. Ka mor'a moo, mabotho a sa tšoaneng liteko laboratoring. Ka ho khetheha, ba mali a le mamello batho e etswa diteko tsa ho ba teng ha batshwai bao e seng e itseng ea ho ruruha, e leng fibrinogen C-arabelang protheine,, alpha-2-globulin. Le ho etsa lipatlisiso tšoaroa ka ho ba teng ha phelang batshwai immunological tse itseng bakeng sa lefu mong le e mong.

Hangata, e le hore ho hlahloba ka ho feletseng boemo ba mokuli, biopsy o etsoa. Noa disampole bakeng sa ho hlahloba lisele mesifa, letlalo, a liphio, e kopanetsoeng synovium.

Ho na le lisebelisoa tsa ho etsa lipatlisiso le ho thusa ho hlokomela mafu a kang collagen. Phumano e kenyeletsa X-ray hlahloba manonyeletso le masapo. Ka litšoantšo ngaka ka boloka litšobotsi tsa ba bang ba mafu a connective dinama tse nyenyane tse, ho akarelletsa le osteoporosis, liphetoho bokaholimo articular le aseptic necrosis, narrowing ea mapetsong kopanetsoeng le joalo-joalo. D.

Ho tloha ka collagen e atisa ho tsamaisana le diso tsa litho tse ka hare ke habohlokoa e le tsa ultrasound ea mpa, liphio, e mesothelioma cavity ea pelo (echocardiography). Ho phaella moo abeloa k'homphieutha kapa a khoheli a gomoso tomography, eo lumella ho lekola boemo ba phelang, hammoho le tšenyo e bakoang ke litho tse ka hare le masapo.

kalafo lithethefatsi tsa mafu collagen

Eo phekolo hloka collagen? Kalafo ea mafu a sehlopha sena lokela ho hakaalo ba li rarahane. phekolo sekemeng o entsoe ka bomong, joalokaha e itšetlehile ka mofuta o le sethaleng sa lefu lena le, ho ba teng tsa mafu pataganeng, ea lilemo li mokuli.

Ho tloha kollagenozah hlokomela ho ruruha ya dibopeho connective dinama tse nyenyane tse, ho bakuli ba pele ba beuweng lithethefatsi-ba khahlanong le a hlabang. Ka mekhahlelo ea pele ea ntshetsopeleng tse atlehang ka ho batho bao e seng steroidal lithethefatsi, haholo-holo ba hore na ibuprofen.

Maemong ao, haeba lefu lena le tsoela pele ka potlako haholo, ka leqheka la ea phekolo laolwa glucocorticosteroids, o na le ho feta phatlalletsoang-ba khahlanong le a hlabang thepa. Ka kakaretso sebediswa "prednisolone" (palo e kahodimodimo ea letsatsi le letsatsi lethal dose ho na ho feta 15 mg,).

litholoana tse molemo ba fumanoa ka kalafo le lithethefatsi cytotoxic ( "Azathioprine", "Tsiklofofamid"). kalafo joalo e laolwa haeba steroid ba ne ba sa fa phello batlang kapa a etsa hore e matla liphetoho boima.

Kalafo ya lefu ka a hlobaetsang le a ileng ae etsa ka sepetlele. Bakuli li ne li lokolloa sepetlele ka mor'a feela ba tla khona ho sebetsana ka katleho le matšoao a ka sehloohong. Ho bohlokoa ho ikamahanya le mokgwa wa nepahetseng tsa mosebetsi 'me ba bang, hammoho le latela lijo, eseng feela ka a hlobaetsang le, empa hape ho pholletsa le bophelo.

mekhoa e meng kalafo

Seo liphekolo tse ling tse hlokang collagen? Phekolo ke ke ho hlokahala, eseng feela ka a hlobaetsang le, empa hape ka nako ya a lekanyelitsoeng boiketlo ba 'mele. E le hore ba fokotsa letotong la lefu lena le, hemocorrection sebelisoa mekhoa, ka ho khetheha hemosorbtion le plasmapheresis. Ba bang bakuli ba hape ho kgothaletsa phekolo 'meleng. Haholo litholoana tse molemo ka finyelloang ka dithuto kamehla ea magnetotherapy, iontophoresis, phonophoresis.

Ka ramatiki 'me ba bang maloetse a mang o ne a tla ba molemo ho phekola ho ikoetlisa, e leng tla thusa ho boloka tsamaiso e tloaelehileng. Bakuli ba eletswa ho kamehla Spa kalafo mekhatlo ngollana profil. Ka ba bang ba mafu a ea collagen le phello e ntle o fuoa radon, sulfide hydrogen le libaka tsa ho tola carbon dioxide. Ke 'nete hore Melao ea lokela ho ikemisetsa ka ho ngaka ho itšetlehile ka lefu mefuta, ea lilemo li le boemo ba motho ea kulang.

mehato e thibelang e ka le ho weather forecasts bakuli

collagen lefu (efe kapa efe ea mofuta oa eona) e tšoauoa ka tsoelang pele e le 'nete hore foleng. phekolo lithethefatsi etsa ho ka khoneha ho fokotsa ponahalo ea lefu lena le le ho fihlela e feta kapa ka tlaase nako e telele ho leballa motho. Leha ho le joalo, hore ba khaotse ho ka ho feletseng lefu lena le ke hoo e ka bang ke ke ha khoneha. Haholo-holo kotsi ke systemic collagen, eo hangata e fela ka tsoelo-pele ea matšoafo a hlobaetsang le ho hloleheng cardiac.

Noa li-hormone le immumodulyatorov sebele bohlokoa. Empa bakuli ba lokela ho hlokomela boemo ba bophelo bo botle le ka ho leballa motho, kaha sena se tla re thusa hore defer aggravation ncha. Bakuli ba lokela ho ho eletsa ho qoba ho pepesehela lintlha precipitating, ebang ke khatello ea kelello le matla le disruptions hormonal kapa hypothermia haholo le letsatsi ka tsela e feteletseng ho pepesehela. Ka ho ba teng ha lefu leha e le tšoaetsanoang, hang-hang ho batla kalafo. Foci la ho ruruha le sa foleng le bona ba na ho inehela phekolo e lekaneng.