Moriana 'MabThera'. Litaelo tsa tšebeliso

The sehlopha sa lithethefatsi anticancer kenyeletsa lithethefatsi "MabThera". Tlhaloso moriana o bontša matla a ho ho toba tlama ho transmembrane antigen teng 95% ya lymphomas bao e seng Hodgkin e, mofuta o B-seleng. Active motsoako - rituximab.

Medicine "MabThera". Litaelo: ya litatoli na

Litlhare tseo ke li behetsoeng lymphoma B-seleng ea batho bao e seng Hodgkin e reng:

- himioustoychivoy kapa iphetang, CD20 ea HIV le tlaase sehlopheng kapa follicular;

- follicular boraro kapa la bone sethaleng hammoho le phekolo ea lik'hemik'hale bakuli sa pele e neng e pepesa hore kalafo ya;

- ka mor'a Karabelo follicular ho phekolo induction ka tšehetso ho bolela;

- CD20 ea HIV B-kholo-hammoho le ratha ka chemotherapy sekemeng.

Le bolela "MabThera" pukwanana khothalletsoang hore foleng lymphocytic kankere ea mali :

- hammoho le phekolo ea lik'hemik'hale ho bakuli ba sa kang ba li behiloe tlas'a kalafo tekanyetso;

- iphetang kapa himioustoychivom hammoho le chemotherapy.

Moriana o bontša batho ba baholo ka foromo mafolofolo tsa ramatiki hammoho le moriana o le "MTX" tšoanelehe ha sebelisoa likarabo hypersensitive kapa regimens phekolo.

Contraindications

Le bolela "MabThera" thuto e sa kgothaletswa haeba u hypersensitive.

Temoso lokela ho sebelisoa ha taolo lithethefatsi ho bakuli ba arrhythmia, angina, congestive ha pelo, phahameng kapa tlaase khatello ea mali, thrombocytopenia, neutropenia, COPD (ka lebaka la ho kgonego ya ketsahalo ea bronchospasm).

litla-morao

Ka ho sebelisa lithethefatsi "MabThera" E se eka bakela ho nyekoa ke pelo, bohloko ba ka mpeng, ho hlatsa. The liponahatso mpe hape e kenyeletsa orthostatic hypotension, arrhythmia, tachycardia, bradycardia, kholofalo ea mosebetsi renal, edema pheriferale, bohloko ka sefubeng le lumbosacral mokokotlo area. Lithethefatsi "MabThera" ho ka etsa hore pheriferale neuropathy, neuritis, ho otsela kapa lefu la ho hlobaela, pherekano kapa ho tepella maikutlo, ho tšoenyeha, ho fokola, ho tsekela, ho utloa bohloko ka hlooho. liketsahalo tse bohloko nkoa e le e alejiki itšoara joang. The halefe ha u sebelisa lithethefatsi "MabThera" litaelo tse rhinitis, pharyngeal edema kapa leleme bokhutšoanyane phefumoloho, bronchospasm, letlalo itchy, boima ba 'mele tlaase' mele, ho hloka taolo ya tatso, ha thothomela hohle, chills, feberu, ho utloa bohloko ka sebakeng molala 'me ka sebaka sa hlahala diriswa, ntshetsopele ya herpetic tsoaetsanang.

litekanyetso li behoa

moriana o laolwa ke lieha intravenous Infusion. Ha monotherapy e sebediswa hang ka beke ka 375 mg, ka libeke tse 'nè. Sekhahla ea pele ea ho tsamaiso ea ea pele ea 50mg / H. Ho eketseha ho palo e kahodimodimo (400 mg, / h) e lokela ho ba butle-butle sekhahla.

lemosa

Mashome a mararo ho metsotso e mashome a tšeletseng pele ho tsamaiso kgothaletswa premedication (ho lokisetsa) le analgesics le lithethefatsi antihistamine.

Nakong ea phekolo, 'me ka hare ho likhoeli tse leshome le metso e ka mor'a ho phethoa ea basali ba lilemong tsa ho ba le bana ba lokela ho sebelisa lithibela-pelehi ka tšeptjoang.

lithethefatsi Antihypertensive lokela ho khaotsa bonyane lihora tse leshome le metso e pele tsamaiso ea lithethefatsi "MabThera".

Ha e thehilweng bohlokwa ba tsamaiso le polokeho ya lithethefatsi ka bana.

Ka ho lokisetsa "MabThera" e bolela ho tswa ho litsebi hangata khothatsang. Ho feta moo, mokhoa oa ho diphuputso, ho ile ha fumanoa hore ha ho khethoa hang-hang ya lithethefatsi ka monotherapy le, hammoho le ho sebelisa latelang ho oona e le tšehetso e bolela ka lilemo tse peli lowers kgonego ya ntseng a mpefala la lymphoma follicular.