Taelo ea "Simvastatin" ea moemeli bakeng sa ho sebelisoa e le lithethefatsi tsa hypolipidemic, e leng karolo ea sehlopha sa statin 'me ke inhibitor of reductase mofuta oa HMG-CoA. Lithethefatsi tsena ke prodrug, hobane ka sebopeho sa eona ho na le lesela le koaloang, le bitsoang lactone, eo ka mor'a ho kenngoa ka 'mele oa motho e leng hydrolyzed. Tšebeliso ea lithethefatsi "Simvastatin" (taelo ea tšebeliso ho sena e hatisa tlhokomelo e khethehileng) e thusa ho fokotsa litekanyo tsa mali tsa triglycerides le lipoprotein, hammoho le k'holeseterole eohle. Ka nako e tsoanang, phello ea phekolo e qala ho hlaha, matsatsi a ka bang 12 ho isa ho a 14 ka mor'a ts'ebetso ea tšebeliso, 'me sephetho se phahameng se fihletsoe ka beke ea bone ho ea ho ea botšelela.
Lithethefatsi tsena li hlahisoa haholo-holo ka sebōpeho sa lipilisi tse pota-potileng biconvex. Sebopeho sa motsoako ka mong e le sejo se seholo sa mafolofolo ke li-milligramme tse mashome a mabeli tsa simvastatin. Likarolo tse ling ke tsoekere ea lebese, polyvinylpyrrolidone, calcium stearate, citric acid, hypromellose, microcrystalline cellulose, butyl hydroxy anisole, acid ascorbic, starch ea poone, titanium dioxide, talc le macrogol 4000.
Ho fana ka lithethefatsi tsa hypolipidemic "Simvastatin" taelo ea tšebeliso e sebelisoa, ka mohlala, bakeng sa phekolo ea batho ba nang le lefu la pele la hypercholesterolemia. Leha ho le joalo, sebelisa sesebelisoa sena tabeng ena e lokela ho ba feela haeba ho se na phekolo ea phekolo ea meriana. Bakeng sa phekolo ea hypercholesterolemia e kopantsoeng, ho lokisetsa "Simvastatin" ho boetse ho ntle haholo. Litlhaloso tsa ho hlalosa li kenyelletsa lefu le kang hypertriglyceridemia.
Nka matlapa ana a haneloa ho batho ba nang le mefuta e bohloko ea tlōlo ea sebete, hammoho le ho hloleha ha liphio tse matla. Haeba ho se lumellane ho simvastatin kapa efe kapa efe ea likarolo tse thusang, litsebi li khothaletsa ho qoba ho sebelisa lithethefatsi tsa "hypovigatin" "Simvastatin". Litaelo tsa tšebeliso ha li lumelle ho fana ka meriana ena ho bakuli ba ka tlase ho lilemo tse leshome le metso e robeli, basali ba bakhachane le bo-'mè ba banyenyane ba anyesang. Ka tlhokomelo e kholo u lokela ho sebelisa lipilisi tsena bakuli ba nang le sebete, lefu la hypotension kapa lefu la sethoathoa. Kaha o na le joala bo sa feleng le lefu la sephio se matla, moriana "Simvastatin" o lokela ho nkoa feela tlas'a tlhokomelo ea ngaka. Ho phaella moo, lethathamo la li-contraindication tse lekanyelitsoeng li kenyelletsa molumo o eketsehileng le o fokotsehileng oa mesifa ea masapo.
Ha e le litla-morao tse ka hlahisoang ke tšebeliso ea lithethefatsi "Simvastatin", pele ho tsohle, mona re lokela ho totobatsa kotsing ea ho ba le tšoaetso ea mafu, pherekano ea methapo ea pelo, arterial hypotension, myopathy, lupus-like syndrome, rhabdomyolysis le thrombocytopenia. Ho phaella moo, ho tepella, ho ba le setulong sa mokokotlo, ho theola maikutlo, ho lahleheloa ke takatso ea lijo, angioedema, ho phatloha ha letlalo, hyperemia, urticaria, eosinophilia, photosensitivity, vasculitis, fever, mesrest paresthesia, anemia le alopecia.