Interferon batho - thepa tsa likokoana-hloko

Interferon batho ho ile ha fumanoa ka 1957 ke bo-rasaense ba tse peli Isaacs le Lindemann. Thanks ho sibolloa ena e mochine e ncha bakeng sa ho sireletsa li-cell batho e se e thehilweng khahlanong le tšoaetso ea bongata ba kokwanahloko. Mocheso-inactivated ntaramane bangodi kokoana-hloko li ne li bolokile ka mahe, homogenised horionalantois 'me ba fumana hore ho supernatant thibela kgolo ya ea kokoana-hloko ea chesehang ea mafolofolo ka horionalantoise. Ntho e 'A e neng e le homogenates e ile ea bitsoang interferon, le o ikhethang tsa likokoana-hloko thepa ea lona bakeng sa lilemo tse ngata o ne a lumela tšireletso ea antivovirusnuyu. Ho ile ha fumanoa hore bahlahisi ba interferon ke lisele tsa lisele tse sa tšoaneng tsa botho le ho liphoofolo. sebopeho lona o susumetsoa ke livaerase, libaktheria batla nyenyane, li-fungus pathogenic, protozoa, tšusumetso mitogens polymers maiketsetso. Leukocytes khona ho susumelletsa interferon tswakana ka mor'a lihora tse 3-4 ka mor'a kokoana-hloko poloko.

Re lokela ho hlokomela hore lipono tse makatsang tsa tshitsiso bongata ba kokwanahloko e telele e tsejoa. E thehiloe bokgoni tšireletso ea batho khahlanong le ketso ea vaerase virulent ka thuso ea lintlha tsa itoanela nonspecific, haeba ka nako e tšoanang kapa pele ho mele oo o fumana tlase kotsi vaerase eo. Ho hong ho kang hona, ke hore, lipono tse makatsang tsa tshitsiso e hlokomela har'a likokoana-hloko baktheria ka mokhoa oa ho sebelisana bona. Ho ile ha fumanoa hore mefuta e 'ngoe ea pathogen ka thibela metsoako ea ho ikatisa tsa mefuta e' ngoe, 'me kahoo fetola tsela ea etsa hore ba tšoaetso. E bontšitse hore ha ho motho ea nang le tšoaetso kapa brucellosis liphoofolo, ba hlahisa maloetseng ho koatsi. O ile a hlalosa tshitsiso pakeng tsa baktheria brucella le tularemia. Ho na le lebaka la ho nahana hore ho na le tshitiso ya libaktheria e hlahisoang e sesitisa hore ho na le masakana lisele kutlo ka macro-phelang hore baka maemo a sa thabiseng bakeng sa ho ba teng ha ho e nngwe ya likokoana-hloko gaisana mo.

Ho ea ka ya data tsa morao tjena, ho na le mefuta e meraro ea interferon (sa gamma-boitshireletso, fibroblast tsa beta le alpha, leukocyte interferon), eo fapana ka hlahang ho yona, a 'mele le lintho tse khethollang likokoana-hloko. E tlameha ho ka boleloa hore ho na le tshitiso pakeng tsa likokoana-hloko o etsoang tsoa le ho thuso ea sesitisa khethehileng eo e tsa maiketsetso ke lisele tse tšoaetso phelang.

Bontšitse hore interferon batho - sehlopha sa amanang peptides biologically mafolofolo, tse thehoa ka lisele tsa tsona li ka mor'a tlhotlheletso ke inducers fapaneng. Ea mahloriso ea interferon hore ke khona ho thibela mosebetsi likokoana-hloko tsa likokoana-hloko e fapaneng 'meleng, bo fapana haholo ka matla. nahanela ho fetisisa ho nka khato ea interferon ipakile likokoana-hloko le sa ka ntle shell a 'me lipid dikarolo (miksovirusy, arboviruses, sekholopane kokoana-hloko), le picornaviruses athe adenoviruses bosula le bo sa enfelopo le ka ntle' me ba ho feta manganga ho Ntlha e ena. Leha ho le joalo, ho na le ntle le mabaka a ha likokoana-hloko le enfelopo ena, pontso ea eketseha ho hanyetsa ketso ea interferon (herpes likokoana-hloko).

interferon batho

The susumetsa ka sehloohong bakeng sa sebopeho lona tse ngata nahana ka ho kenella ka hare ea lisele baditjhaba acid e nucleic, e tlōlang e tloaelehileng liphatsa tsa lefutso ho leka-lekana ba lihlopha tse sa tšoaneng tsa lisele tsa. hlasimollang A molemo phetha kokoana-hloko nucleic acid e liseleng vertebrate phoofolo, le hoja tse ling tse acid nucleic ka sebeletsa e le inducers tsa interferon. Har'a metsoako ea lisele tse sa bonahaleng tse tse tšoauoa ka e le hantle interferon, karolo ea bohlokoa e bapaloang ke endotoxins ea libaktheria mob mobile-mpe le hape lipopolysaccharides le polysaccharides, ka ho khetheha pirogenal, prodigiozan. Interferon e hlahisoang ke lintho tseo batho ba le tlas'a tšusumetso ea phages RNA le likokoana-hloko, tse hantle sireletswa ho phello inhibitory tsa ribonuclease.

Mabapi le dipharologantsho tsa interferon, a, ho fapana ho inhibitors e tsebahalang ho nka bohato ka kokoana-hloko ea ho toba ama ba ka lisele tsa mamela, ea etsang hore ba manganga ho ho ikatisa bongata ba kokwanahloko. Ho interferon ka bontša le phello antiviral, lisele tse nahanela e lokela ho ba sa khathatseha tswakana tsa RNA lisele le liprotheine lisele.

Morao tjena, e le moemeli antiviral laolwa "batho recombinant interferon Alfa 2". antiviral bohato mochine e amanang le ho bōptjoa ha mekgwa sireletsang neinfetsirovanyh kokoana-hloko liseleng. Sena se fetola thepa ya lera la seleng, eo thibela ho kenella ka hare ea kokoana-hloko ka seleng.

The thepa tsa likokoana-hloko e kenyeletsa interferon mefuta khethehileng, e bolelang khetha ponahatso ea mosebetsi 'meleng oa mefuta e tsa lona homologous. Mohlala, interferon hlahiswa lisele tse khoho embryo, a ke ke a sireletsa litoeba kapa liphoofolo tse anyesang tse ling, 'me interferon hlahisoang ke leukocytes batho, ha a na mosebetsi ka liphoofolo. thepa ena e sa ka ho feletseng, 'me ka maemong a mang, interferon hlahang ho yona heterologous a ka le mafolofolo' meleng oa mefuta e 'ngoe.