Anticoagulants - lithethefatsi tse amang mali a hoama

Tlas'a maemo a tloaelehileng, mali ke mokelikeli eo e fana ka motsamao oa tsamaiso oa hae ho potoloha ha mali. Ka mafu a tšoaetsanoang le parasitic, hammoho le intoxications fetola physico-lik'hemik'hale lona thepa, eo hampe ama dithulaganyo tshilong ya dijo le ea ka tšebetso ea litho tse ka hare. Ka tsela eo bohlokoa tsa likokoana-hloko e na le sekhahla hoama. E ka potlakisa le lieha. Ka moriana, sebelisa e ngata mahlahana diokobatsi ka thuso ea tse o ka fetola lebelo la hoama ea mali. Anticoagulants - lithethefatsi tse fokotsa lebelo ho tshebetso ya ho coagulation mali, e le mokhoa oa ho potlakisa ka karabelo ena e sireletsang, e bitsoang coagulants.

The mochine oa coagulation le thrombus sebopeho - e rarahaneng skeletal mosebetsing ona ho sireletsa 'mele ho tloha ho lahleheloa ke mali ka nako vascular botšepehi ba tlōla. Tshebetso ena e etsoa ka ho qhekella prothrombin, e leng e tsa maiketsetso ka sebete, 'me li-platelet, eo ho ikamahanya le collagen likhoele tsa molekeng oa sejana senyehile. Mosebetsing oa ho hydrolysis abelwa metsoako platelet e ngata (adenozintrifosfatnaya le asiti adenozindifosfatnaya), thromboplastin le vasoconstrictors - norepinephrine, epinephrine, serotonin. Ba tšesaane sejana lumen. Thromboplastin tlas'a tšusumetso k'halsiamo le lero la mali le liprotheine tse amanang le prothrombin le thrombin liforomo, tse ke protheine (fibrinogen) ea e sokolohela fibrin insoluble, ho tiisoa ha ho vascular lumen.

Mali hoama, ae fokotsang lebelo mafu tse amanang le maemo fokotswa k'halsiamo maling, ho fokotseha ka platelet bala, prothrombin tswakana hloka taolo ya fibrinogen thrombokinase mosebetsi lekaneng le vithamine K. The coagulants sebelisoa ka meriana, thrombin, fibrinogen k'halsiamo chloride, menadione, acid e aminocaproic, meroho litokisetso (makhasi bobatsi, metsi pepere).

Anticoagulants - lithethefatsi tse thibela metsoako mosebetsi likokoana-hloko ea tsamaiso, eo e fana ka mali coagulation le thibela sebopeho sa clots ka methapo ea mali. Ba thibela metsoako tsohle kapa tse ding tsa mekhahlelo e sa hoama ea mali. E o tsejoa hore mali mokelikeli boemo e hlokomelwa ke enzyme e itseng le antitrobminom. E le hore ho thibela sebopeho sa clots mali, anticoagulants sebediswa ketso e tobileng. Ba ama mali hoama lintlha lieha tshebetso ka 'mele kapa tube,. Sodium citrate (sodium citrate) le EDTA (acid e ethylenediaminetetraacetate) tlama le k'halsiamo ionized mali le sokolla hore e be k'halsiamo citrate ka complexed le EDTA. Mabapi le ho tlosoa ha ions k'halsiamo ho tloha tsamaiso ea mali hoama Ho thehoa thrombin le fibrin. Heparin inactivates lintlha thrombogenic le thibela tšokoloho ea prothrombin ho thrombin. Anticoagulants - ketso e tobileng ea lithethefatsi tseo ke li behetsoeng tšeloa le hematology laboratori ea lithuto tsa bakeng sa thibelo ea hoama mali le bakeng sa kalafo ya mafu a tse tsamaea le e potlakisa hoama ea mali. lithethefatsi tsena li sebelisoa bakeng sa ho thibela le kalafo la mathata thromboembolic.

Anticoagulants ba sa tobang bohato - bishydroxycoumarin, coumarin, sinkumar - thibela tswakana tsa enzyme tse amehang hoama ea mali. Ba thibela metsoako thrombin sebopeho ka sebete. Tshebetso ena develops ka phelang ka hare ho lihora tse 12-72 le ho bontšoa e le nako ea matsatsi a ho tloha tse peli tse ho tse leshome. Ena ke meriana nako e telele-ho nka bohato. Anticoagulants - lithethefatsi sa tobang balletsweng bakeng sa ho thibela le kalafo ea thrombosis, embolism, thrombophlebitis.