Lithethefatsi Antileukotriene ba moloko o mocha: lethathamo la molemo ka ho fetisisa

lithethefatsi Antileukotriene emela sehlopha sa mocha oa mahlahana hore fokotsa dithulaganyo hlabang tse alejiki kapa a tšoaetsanoang etiology.

E le hore re utloisise molao-motheo oa ketso ea lithethefatsi tsena li ka, ho ke ke ho hlokahala hore ba utloisise seo ke leukotrienes.

leukotrienes

Ba mediators la ho ruruha. Ho ea ka sebopeho bona lik'hemik'hale, ba acid tse mafura, tse thehoa ea acid e arachidonic.

Leukotrienes ameha ntshetsopele ya asma. Hammoho le histamine, ba mediators ya kulisa tsa mofuta o hang-hang. Histamine ka etsa hore ka potlako empa nako e khutsoanyane bronchospasm le leukotrienes bakela tsoarelloa le sa spasm.

E le lithethefatsi classified antileukotriene?

Jwale, leukotrienes ba classified e le e latelang: A _4, B _4, C _4, D _4, E _4.

Tswakana tsa leukotrienes tswang acid e arachidonic. Ke tlas'a tšusumetso ea 5-lipoxygenase tsoela ho leukotriene A _4. Ka mor'a hore ho na le phorosela itšoara joang, e leng se ile sa fella ka tse latelang foromo leukotrienes B ₄ -C ₄ -D ₄ -SU _4. Sehlahisoa ho qetela ea kamoo ba ileng ena - LTE _4.

E thehilweng hore LTE _4, D _4, E ₄ ka etsa hore bronchoconstrictor le hantle, keketseho ea mucus secretion ka 'na kenya letsoho hore ho ho hōla ha edema, thibela metsoako mucociliary rengwa.

B _4, D _4, E ₄ na mosebetsi chemotactic, i.e. e ka hohela neutrophils le eosinophils ka a hlabang libaka tshebetso.

Bo-rasaense ba 'nile ba bontša hore leukotrienes tse hlahisoang ke macrophages, lisele tse palo, eosinophils, neutrophils, T-lymphocytes, tse ameha ka ho toba ka liphetoho a hlabang. lithethefatsi Antileukotriene ka asma e atisa ho sebediswa.

Mora lisele tla kopana le e allergen le tsidifatso hlahile Lufthansa kapa mora Mokhathala meleng, butswe LT tswakana. Ke hore, tswakana qala ha osmolarity tsa bronchial eketseha dikahare.

lihlopha tse 'nè tsa lithethefatsi

Hona joale e tsejoang ka lihlopha tse 'nè antileukotriene lithethefatsi:

1. "Zileuton", eo e leng sesitisa e tobileng ea 5-lipoxygenase.
2. Formulations tse inhibitors tiske, lemosang tshebetso ya ho tlama le protheine ka acid e arachidonic.
3. "Zafirlukast", "Pobilukast", "Montelukast", "pranlukast", "verlukast" tse ba khahlanong le lōna ba receptors leukotriene sulfidopeptidnyh.
4. Lithethefatsi tse ba khahlanong le lōna ba leukotriene B ₄ receptor.

Ka ho fetisisa o ile a ithuta ke lithethefatsi antileukotriene tsa sehlopha sa pele le sehlopha sa boraro sa chelete. Nahana ka lihlopha tsena ka hloko.

"Zileuton"

"Zileuton" ke sesitisa reversible of 5-lipoxygenase. Ho kgona ho thibela metsoako sebopeho sulfidopeptidnyh The LT le RT _4. Lithethefatsi ka 'na ba le litla bronchodilator hlolang ka nako e fihlang ho lihora tse hlano. Hape e khona ho thibela ketsahalo ea spasm bronchial, e leng ka lebaka la ho pepesehela moea batang kapa "aspirini".

lithuto tse ngata li bontša hore "Zileuton" abeloa ho bakuli ba nang le ho tloha le asma e bronchial likhoeli mong ho ba tšeletseng, ho ka fokotsa hore ho hlokahala hore ho ba le mamello ho hema β2-agonists le corticosteroids. A le 'ngoe lethal dose "zileuton" lemosa ketsahalo e sa e thimola le bokhutšoanyane hema nasal bakuli ba tšoeroeng ke alejiki rhinitis mor'a tsamaiso nasal tsa allergen.

Tse tšeletseng ka beke phekolo le "zileuton" atopic asma o ile a bontša lebaka bohlokoa. Lingaka li re boleng bo phahameng theola tsa eosinophils le neutrophils. Hape, ho fokotseha hlahala necrosis le palokatiso marong bronchoalveolar lavage mora allergen mofuta teko. Seo ke sona seo ke antileukotriene lithethefatsi ikhethang, le mochine oa ketso e thehiloe holima ntho ena.

"Zileuton" e tšoauoa ka nako e batlang e le khutšoanyane, e leng nakong eo ho na le lona halofo bophelo. Sena se bontša hore ho ea lithethefatsi lokela ho ho nkoa ka hangata ka ho lekaneng hore ka makhetlo a mane ka letsatsi. Ho phaella moo, "Zileuton" ea nang le bokhoni ba ho fokotsa rengwa theophylline. E lokela ho nkoa e le, haeba ho e nka e tšoanang bozongisela theophylline le "zileuton". Ke hore, lethal dose ea pele e lokela ho tsa fokotswa. Ha "Zileuton" abetsoe ka nako e telele, ho ke ke ho hlokahala hore ho hlokomela boemo ba enzyme sebete.

Empa ho na le antileukotriene moloko o mocha oa lithethefatsi, lethathamo bona e bontšitsoeng tlaase mona.

Mahlahana a tse di ba khahlanong le lōna ba leukotrienes sulfidopeptidnyh, le baphadisani ba haholo khetha le reversible blockers LT D ₄ receptors. lithethefatsi tsena li akarelletsa "pranlukast" "Zafirlukast", "Montelukast."

"Akolat" ( "Zafirlukast")

"Zafirlukast" aka le "Akolat" ke ho fetisisa o ile a ithuta tsa sehlopha sena sa dintho lithethefatsi antileukotriene. Ho boetse ho na le motho ea mafolofolo bronchodilator tlwaetso. phello ea nka bakeng sa haholo nako e telele, ho fihlela ho lihora tse hlano. "Zafirlukast" thulaganyou e ke khona ho thibela ntshetsopele ya e asthmatic itšoara joang tabeng ea ho allergen inhalation. katleho lona e proven, le thibelo bronchial spasm, e leng e halefisoa ke moea a batang, aspirini, ho ikoetlisa, kgotlelo. Active lithethefatsi, 'me ba lokisetsa ho "Montelukast" khona ho ntlafatsa bronchodilator mosebetsi oa β2-agonists.

"Akolat" ( "Zafirlukast") na absorbability molemo, tlhōrō ea mahloriso ea eona ea mali e fihlellwa ka mor'a lihora tse tharo ka mor'a hore tsamaiso ea eona. halofo ea bophelo ba eona nako ea ho hanyenyane ho feta ho "zileuton", 'me ke qeta lihora tse ngata 10. Ho phaella moo, bo se na le phello e rengwa theophylline. Amohela a sebetsang a lithethefatsi e lokela ho ba ka hora pele lijo kapa ka hare ho lihora tse peli ka mor'a moo, ho tloha lijo haholo ho fokotsa absorption bokgoni lona. Ho bolela mameletse hantle.

bofello

lithethefatsi Antileukotriene bakeng sa kulisoa ka sebelisoa bakeng sa bana, empa eseng pele ba fihla a le lilemo li peli. Ka thuso ea meriana tsena ka bana ba tšoaroa ka la bronchitis iphetang, alejiki rhinitis, le asma e bonolo.