Lithethefatsi "Akineton": litaelo bakeng sa ho sebelisoa, tlhaloso, ulasan pelanggan

Ntho a sebetsang a "Akinetona" ke biperiden hydrochloride. Letlapa ka bolulo ho 2 mg, ea boleng bo sebetsang. Ho feta moo, ho ba teng ha metsoako eketsehileng (poone starch, starch litapole, lactose monohydrate, magnesium stearate, microcrystalline selulose, copovidone, k'halsiamo hydrogen phosphate dihydrate, talc, metsi e ba a hloekileng) a qala ho ba lithethefatsi "Akineton".

Litaelo tsa tšebeliso, photo photo photo photo e bontša hore letlapeng mofuta o mong oa lithethefatsi o na le hoo e batlang e 'mala o mosoeu, Valium foromo. Ka lehlakoreng le leng la letlapa ho na le kotsi ya beveled sebopeho sefapano.

1 di ml tharollo na biperiden lactate ka palo ya 5 milligrams. dikarolo tse eketsehileng di: injecting metsi le sodium lactate.

litla diokobatsi

Main motsoako biperiden - holinoblokator bohato bohareng.

Sephetho akarelletsa nyahamisa leng bokhoni ba ho mosebetsi cholinergic neuronal ka striatum, e leng ke mehaho unit trust ea tsamaiso extrapyramidal.

Lithethefatsi baka phello e ganglioblokiruyuschimi, ho tiea limithara-anticholinergic litla antispasmodic le e leka-lekaneng ka periphery (antispasmodic).

Tšebeliso ea lithethefatsi le thusa ho felisa leoto tremor, eo ho hlaha ka tšebeliso ea lithethefatsi cholinergic (mohlala, pilocarpine) le catalepsy le mesifa se tenyetsehe ka bakuli ba fumana neuroleptics. Ho na le matla a ho re susumelletsa pherekano.

Pharmacokinetics

"Akineton" tlangwa ho liprotheine lero la mali ka 91-94%. Lero la mali rengwa tla 11,6 ± 0,8 di ml / mets / lik'hilograma boima ba 'mele. A lethal dose ea se nang molekane ea paakanyong molomo o na le bioavailability tse ka bang 33 ± 5%.

Fetelang ka lebese.

Biperiden botlalo metabolized ka 'mele oa motho. Ka moroto, ntho e sa ikemisetsa foromo unaltered. The metabolites kgolo di bicycloheptane le piperidine, tse khumo tswa mantle le moroto.

Elliminatsiya etsoa mekhahlelo e 'meli, e nang le bophelo ba halofo (T 1/2) ea metsotso e 90 ka nako ya mohato pele' me lihora tse 24 - mohato bobeli. Bakuli ba hōlileng, le halofo ea bophelo ba ka eketsa haholo.

ho bonahala

"Akineton" le sebelisitsoeng ho mafu a extrapyramidal hlohlelletsoa ke tsamaiso ea meriana e itseng (neuroleptics, antipsychotics).

Hape, lithethefatsi e bontšoa ho fumanoe tsa lefu lefu Parkinson, parkinsonism (moemeli tsamaisoa ka phekolo hammoho le oa botlaaseng a)

Contraindications

Ka morero oa ho ea lithethefatsi ena e sa kang a bontšoa ha u hypersensitive ho motsoako mesebetsi e amanang le lithethefatsi "Akineton".

Litaelo bakeng sa ho sebelisoa tsebisa hore lithethefatsi lokela ho qojoa ka phumano ya lefu ka mamello kang ea tšoelesa ea senya kholiso, angle-koalo glaucoma, liphetoho obstructive ka intestine le (pylorus stenosis, ea shoeleng litho ileus Genese).

Arrhythmia, sethoathoa, fepa letsoele, ea seng a hōlile, ho ima ho na le mabaka a eo "Akineton" laolwa ba hlokolosi haholo.

litla-morao

CNS litla-morao li bonahatsoa asthenia, mokhathala, lethargy, bofokoli, shoohlo, ho tsekela, boikutlo ba ho amehoang ka tsona ka, ho tšoenyeha, kholofalo memori, pherekano, lipono, catalepsy, ho itšetleha lithethefatsi lithethefatsi "Akineton".

Litaelo bakeng sa ho sebelisoa bua ka lehlakoreng-litla le le karolo e itseng ea pono - mydriasis, likhathatso tsa tsa bodulo.

Cardio-vascular tsamaiso e khopo e tšoauoa ka quickening ba otla ha pelo (tachycardia); ka linako tse ling - deceleration (bradycardia); ha ho sebelisa ente mofuta o mong oa ho lokisetsa ho - decreases ka khatello ea mali (hypotension).

Ka lehlakoreng la tsamaiso tshilong ya dijo - omileng molomo, matšoao dyspeptic, pipitlelano.

Ka lehlakoreng la metabolism - fokotseha ho fufuleloa.

Ka lehlakoreng la tsamaiso ea mosese - ka bakuli ba kholiso (hypertrophy) tsa tšoelesa ea senya tšoelesa - thatafalloa khoneha ntša metsi.

kulisa: lekhopho ka letlalo, ho hlohlona.

Mekhoa ea ho Sebelisa

Bakeng sa intramuscular, intravenous, le molomo Letlapa foromo e ho loketse ho lokisetsa "Akineton".

Litaelo bakeng sa ho sebelisoa ho bontša hore phekolo "Akinetonom" kakaretso e qala ho tswa tekanyetso e nyenyane, e lethal dose ho feta eketseha stepwise ho itšetlehile ka a lakatsa e le hantle phekolo le bakeng sa ditlamorao.

Batho ba baholo ka ho sebelisa mofuta o sa molomo oa ho lokisetsa ho qala kalafo ka lethal dose ea la 1 mg, 1-2 baeti ba fihlelang ho motšehare kapa 2 mg, arotsoe ka tekanyetso tse peli ka letsatsi. Ho ekelletsa moo, litekanyetso li behoa ea ka e ile ea eketseha ho 8 mg, a mabeli ho a mane tekanyetso aroloa. Leha ho le joalo, lethal dose lokela ho sa eketsa fetang 2 mg, ka ho ya ka letsatsi. U se ke ua feta litekanyetso li behoa palo e kahodimodimo ho bolela 6 ka Th-16 mg, ka matsatsi a mahlano. Single lethal dose foromo injectable lithethefatsi lokela ho sa feteng 2.5-5 mg,. lethal dose ena ka 'na a pheta ka mor'a halofo ea hora, empa palo ea ditaelo ka letsatsi lokela ho sa feteng makhetlo a 4. The lethal dose palo e kahodimodimo ea moriana o foromo injectable e 20 mg, ka matsatsi a mahlano. Ha lethal dose homolog e fihla, ka nako eo e le phetoho ho ea moketeng oa lijo "liehisa Akinetona."

Empa u se ke ua lebala ka ho sebelisa katamelo e motho e mong ho e le mamello ka ho khethoa biperidenom phekolo.

Extrapyramidal bolwetse hlahang ka lebaka la ho-ja tsa meriana e itseng (antipsychotics kapa neuroleptics) hloka kabelong ya ntho e itseng ka lethal dose e le 'ngoe ea 2 mg, ka molomo kapa parenterally. tsamaiso Pheta ya tekanyetso boletseng le ka ba mong le e mong hora halofo. Leha ho le joalo, joalokaha ho bontšitsoe ka holimo, palo ea ditaelo lokela sa feteng makhetlo a 4. The lethal dose ka molomo e lokela ho arotsoe ka tekanyetso e 'ngoe ho tse tharo.

lefu Parkinson ho akarelletsa ho fana ka lithethefatsi ka molomo ka 6-8 mg, ka 2-4 aroloa tekanyetso bakeng sa ka letsatsi, lethal dose ea ka butle-butle e ile ea eketseha ho fihlela ho 6-16 mg,.

Bana ba ka tlaase morero oa selemo e fana ka maikutlo le monyetla oa ho ea lithethefatsi e ka mokgwa injectable butle, ka lethal dose ea se nang molekane ea 1 mg, kapa 0,2 di ml. Ha lilemo ho tloha selemo se le seng lilemo tse tšeletseng laolwa 2 mg, kapa 0,4 di ml. Tloha ka ba lilemo 6 ho 10 - 3 mg, kapa tse 0.6 di ml. lethal dose ena ka 'na a pheta ka mor'a hora halofo le boemo ba tšohanyetso le. Ka ho ba teng ha litla bohloko ka tsamaiso ea lithethefatsi e lokela ho ba khaolitse ente.
Nakong ea mofuta o le molomo oa phekolo lithethefatsi tsa lilemo tse lilemo tse 3 ho ea 15 ea etellang litekanyetso li behoa ea 1-2 mg, ka mor'a lihora tse 1-3 motšehare.

matlapa a sitoa ho noa ka mpeng ea lefeela, 'me o lokela ho noa e le e leka-lekaneng palo ya metsi. Ka ketsahalo e sa litla sa rateheng-morao ho tloha tsamaiso tshilong ya dijo lokela ho nka lithethefatsi hang-hang ka mor'a lijo, ho fokotsa ho tiea tsa tshusumetso e bohloko le bolela "Akineton".

Litaelo bakeng sa ho sebelisoa ho bontša hore tabeng ea bokoali chefo ka batho ba baholo tekanyetso phekolo e rarahaneng o boetse o laolwa lithethefatsi ena, le lethal dose lona e 5-Th-TB-10 mg, bakeng sa liforomo injectable, empa feela maemong a ka senyang bophelo ba mokuli.

Ha chefo manyolo phosphorus metsoako biperiden dosing o etsoang tsoa le batho ka bomong ho itšetlehile ka ho tiea tsa diso. Qala ho tloha lethal dose e le ba 5 mg, tabeng ea tsamaiso intravenous, tsamaiso pheta tsoela pele ho fihlela matšoao a nyamela chefo.

overdose

Overdose bontša phatlalletsoang litla anticholinergic bakoa ke moriana "Akineton".

Litaelo tsa tšebeliso, lingaka ea sebele lefa a lebisa tlhokomelo ho ha e le hantle hore ho phekola boemo ena posimptomnaya (tokiso ea pelo le methapo le tsamaiso ea ho hema, phekolo oksijene, hyperthermia khalemelo, e mosese catheter sete, haeba ho hlokahala). Hloka ho qaloa ho sa cholinesterase sesitisa (physostigmine haholo-holo) .

sebelisana

"Akineton" ha ho sebelisa limithara-holinoblokatorami, lithethefatsi le e antihistamine le bohato antiepileptic kgothaletsa le pontšo ea e qetellang. Leha ho le joalo, tsoa hong sebelisa metoclopramide fokotsa phello ea oona ho phekola. Ho na le e tobileng lumellane lithethefatsi le ethanol. Ho khethoa ha quinidine eketseha ka makhetlo a kotsi ea ho ba le matšoao a dyskinesia. M-cholinergic le phello e ntlafatsoa ha ho sebelisa levodopa.

Storage le pabatsong

Ho reka lithethefatsi ena hloka lengolo la ngaka ho fana ka pharmacist. Ho boloka "Akinetona" lokela ho etsa lintho tumellanong le mocheso, 't. E. Ambient mocheso lokela ho sa feteng likhato 25 (Celsius tekanyo e). Re hloka ho finyella bana ho setsing "Akineton".

Manual e fana ka raka, athe bophelo ba lithethefatsi - lilemo tse hlano.

lemosa

Kgetho ya biperiden nakong ea bokhachane le ho nyantsha (diabolololo) hloka bontšang tieo.

Biperiden ka fumana ho lesea ka lebese, a etsa hore ho hlōleha ka nakoana kanyeso ho discontinuation ea lithethefatsi "Akineton".

Product tlhaloso o bontša hore ka ho etsa qeto ka ho kgethwa ha biperiden nakong ea bokhachane le ho diabolololo hlokomele kotsi khona ho lesea, lesea.

Ea seng a hōlile e e-ba le palokatiso kotsi bakeng sa kalafo le lithethefatsi ena. Ka lebaka leo, le beha hore "Akineton" sehlopha sena sa batho ba nang le hlokolosi haholo.

Kickaha ba sieo ha bopaki bo leha e le efe ya tshebediso ya tshireletso ka bongoaneng, ke lebaka la hore ha e sebetse ho bana ba lithethefatsi "Akineton".

Tlhaloso ea ho lokisetsa (taeo e pukwanana) totobatsa 'nete ea hore batho ba be hlokolosi, ho hlokahala ha u sebelisa lithethefatsi sena bakuli ba lefu la sethoathoa kapa fibrillation.

Ka tšebeliso ka nako e telele ka 'na ba ea lithethefatsi ho itšetleha.

Kotsi ea lefu a khaotsa ho tsuba le amana le hore cessation butle-butle phekolo "Akinetonom".

tšebeliso ea lino tse nang le tahi lokela ho qojoa nakong phekolo e.

Kalafo le lithethefatsi ena hloka teloe khanna likoloi le lipapali mesebetsi e hlokang mahloriso phahameng le itšoare ka potlako psychomotor, kaha e nkang le eona kotsi ka 'nang ka lebaka la kotsi ea ho tsekela.

"Akineton". Litaelo ho sebelisoa. analogs

Synonymes ho lokisetsa ke dintho tse latelang: "Biperiden" "Mendileks" "hydrochloride biperiden".

"Akineton". Reviews

Lithethefatsi ke atlehang ka ho haholo ka ho phekola Parkinsonism thothomela hohle ka leoto e fediswa mor'a nakoana karohano. O re: hantle mameletse lithethefatsi "Akineton".

Feedback ka diqoqiso ho bua ka monyetla oa ho ponahalo ea litla bang lehlakoreng ha etellang lithethefatsi.

Price "Akinetona". moo ho reka

Litsenyehelo tsa ho ba tharollo ka 'na ba pota 800 li-ruble.

Theko molomo paakanyong "Akinetona" - 560-580 li-ruble.