"Ademethionine": litaelo bakeng sa ho sebelisoa, analogs, ulasan pelanggan

ke eng ntho ademetionine? Litaelo bakeng sa ho sebelisoa tsa ho lokisetsa, e nang le motsoako o tla a hlalosa o bitswang. Re boetse re u bolella mabapi le kamoo e hloka sesebelisoa se tšoanang le hore basebelisi ba reng ka eona, 'me joalo-joalo.

Foromo ya moriana, tlhaloso ea eona

Foromo se fumaneha lithethefatsi "Geptral" (INN "Ademethionine")? Litaelo tsa Sebelisa e bolela hore thulusi ena e fumaneha ka mefuta e 'meli e fapaneng:

• The lyophilizate, o ne a rerile bakeng sa ba lokisetsa ho ea tharollo intravenous kapa intramuscular. foromo ena ke boima lyophilized ba tšoeu, ho se inclusions tsoang linaheng tse ling. Hape, ka lebokoso sosobaneng na le solvent khethehileng le nang le mofuta o mong oa e mokelikeli colorless le sebeletsang pepeneneng.
• "Ademethionine" - lipilisi ka tšoeu enfelopo, biconvex le oval. Ho feta moo homonymous a sebetsang a ntho, hona ho bolela hore akarellelitse le thepa ea motheo ea thusang tse kang MSC, Na-carboxymethyl silica le stearate MG.

litšobotsi tse pharmacodynamic

Seo thepa ya ademetionine ntho? Kopo ya litaelo e fana ka hore o ile a re motsoako lipontsuoa choleretic, holekineticheskoe, detoxifying, neuro- le hepatoprotective le-ba khahlanong le depressant le litla antioxidant.

Kahoo, ho e sireletsehileng ea ho ela hloko hore ho nkoa lithethefatsi elements khonang ho matlafatsa le secretion ea bile, 'me qholotsa karohano lona ka intestine le.

Hape hlokomela hore lithethefatsi "Ademethionine" analogs tse bontšitsoeng tlaase mona, tlatsa ho haella Sam, empa e boetse e di hlohleletsago sebopeho ka sebete. Ho feta moo, hona ho bolela hore hantle eketsa lero la mali mahloriso tsa cysteine, taurine, glutamine dikahare ka sebete, ka hona normalizing le thulaganyo tshilong ya dijo ka sebete le ho fokotsa boemo ba methionine ka serum.

Tlas'a maemo a se bolela "Ademethionine" ka tsela e atlehang ka ho fetisisa? Litaelo bakeng sa ho sebelisoa li bontša hore lithethefatsi enoa o etsa hantle le ductal le tubular e amanang le sebete cholestasis. Ho etsa conjugation LCD le sulfation ka lisele tsa tsona li sebete, 'me joale lowers toxicity bona.

Ho ea ka litlaleho tsa litsebi, choleretic le hepatoprotective litla ka mor'a discontinuation ea phekolo "Geptralom" bolokoa ho fihlela ho likhoeli tse 3.

Ha abela hona ho bolela hore batho ba nang le ho lemalla opioid, lateloa ke lefu sebete, ho ntlafatsa sena mosebetsi lekala monooxygenase dithulaganyo ho kena moea, empa e boetse e thusa ho bofokoli matšoao ea tleleniki ea khaotsa ho tsuba lithethefatsi.

Antidepressant e le hantle ka mor'a ho sebelisa lithethefatsi ena develops butle-butle. Leha ho le joalo, o ile a tla ho tsitsisa fetela ho libeke tse peli tse fetileng.

bolela bokhoni ba kinetic ho

pheko "Ademethionine" ikakhele ka setotsoana? Litaelo bakeng sa ho sebelisoa ea tlaleha hore ka molomo bioavailability lona e 5%, 'me ha u sebelisa ente - 100%.

Tlhōrō ea mahloriso ya lithethefatsi ka mali nakong ea lethal dose ea se nang molekane ea letlapa le e mong o ile a re ka lihora tse 2-6.

The lero la mali nang le protheine e tlangwa boemo ba moemeli ena ke feela ka bongata tse nyenyane. Ho lokela ho hlokomeloe hore lithethefatsi le kenella ka hare hantle ka BBB, 'me ka concentrations phahameng ka habonolo lemoha esita le mokelikeli cerebrospinal.

Biotransformation ea lithethefatsi e pepesa ka sebete. ntsha lona halofo ea nako e lihora tse 1,5. Nkiloeng lithethefatsi liphio.

Bontšang bakeng sa lebitso le ea mokhoa oa ho

Ke hobane'ng ha re hloka pheko "Ademethionine" (theko ea lithethefatsi boletsweng ka tlase)? pheko ena e atisa ho ba laela hore:

• matšoao a ho tepella maikutlo;
• intrahepatic cholestasis le ka re cirrhotic pretsirroticheskih, ho akarelletsa le steatosis e amanang le sebete;
• foleng cholecystitis ntle majoe;
• foleng lefu la sebete;
• cholangitis;
• chefo e amanang le sebete diso se hlahang ho yona fapaneng, ho akarelletsa le bongata ba kokwanahloko joala le lithethefatsi (tricyclic antidepressants, lithibela-mafu, antivirals, antitumor le -ba khahlanong le TB lithethefatsi, molomo lithibela-pelehi);
• ho thatafala ha sebete;
• intrahepatic cholestasis ka bakhachane;
• magazine ho akarelletsa le tse amanang le e amanang le sebete insufficiency (joala).

Ho thibeloa tshebediso ya

Tlas'a hore na maemo a sa lokelang ho e balletsweng ya lithethefatsi "Ademethionine" kapa "Geptral"? Sena se bolela ho se ka sebelisoa ka mafu a liphatsa tsa lefutso tse amang methionine potoloho, hammoho le ho etsa hore hyperhomocysteinemia kapa homocystinuria. Hape e contraindicated ho fumana bongoaneng le lilemong tsa bocha 'me e phahameng nahanela ho ademetionina.

Dosing "Ademethionine" Tablets

Guest litsebi re sebetsana le mokhoa oa ho ho nkoa ka ka ho pakeng tsa lijo hoseng, ha sithabetsa kapa ho hlafuna sethethefatsi. Tabeng ena, letlapeng lokela ho tlosoa tloha ambalaji e ka ho toba pele tshebediso ya.

The litekanyetso li behoa ea letsatsi le letsatsi ea meriana ena ke matlapa 2-4, le bolelele ba nako ea phekolo e itšetlehile ka bopaki bo le teng.

Litaelo bakeng sa ho sebelisoa ea tharollo

Ke lokela ho sebedisa injectable tharollo "Ademethionine" analogues eo e ka fumanoa drugstore efe kapa efe? ho lokisetsa ena rekisoa ampoules, intramuscularly kapa a entoe. Ka tsela eo intravenous ente e phethahatsoa butle haholo.

The tharollo ea lithethefatsi e itokisetsa feela pele ente e sebelisa phofo lyophilized bakeng sa ho hlapholla solvent hore ke ka sephutheloana lebokoso.

Mora ente ea lithethefatsi setseng tlameha ho lahloa.

Re lokela ho hlokomela hore injectable foromo "ademethionine" lumellane le ditharollo alkaline le formulations nang le Ca ions.

The litekanyetso li behoa ea letsatsi le letsatsi ea moemeli bakeng sa TOLC 1-2 ampoules. Kalafo le moriana o ena nka libeke tse peli.

Ha tepella maikutlo lithethefatsi nkoa e sebediswa ka lethal dose tšoanang. Ha ente ena e etsoa ka matsatsi a 15-18.

Ha mokuli a hloka kalafo ea tšehetsang, moo o ile a isoa ho Letlapa foromo "Heptral".

litla-morao

liphetoho life mpe li ka etsa hore meriana "Ademethionine" (400 mg,) hangata nakong kalafo le lithethefatsi sena bakuli le letšollo, bohloko mpeng le ho nyekoa ke pelo.

Maemong a sa tloaelehang le ho sebelisa "Geptral" tharollo, hammoho le eona foromo Letlapa ka etsa hore tsoelo-pele ea:

• IMP (i.e. mosese pampitšana tšoaetso ea);
• laryngeal edema, liphetoho hypersensitivity;
• paresthesia, ho tšoenyeha, hlooho e opang, lefu la ho hlobaela, ho tsekela, pherekano;
• ho hlohlona, liponahatso letlalo la kulisoa, rashes, angioedema, ho fufuleloa;
• ho ruruha ha marako a methapong ka ntle feela, mafu a ea methapo ea pelo le mali, le chesang mahlaseli;
• bloating, molomo o omileng, ho hlatsa, esophagitis, ho nyekoa ke pelo, bohloko ba ka mpeng, letšollo, dyspepsia, mafu a tshebetso pampitšaneng ena tshilong ya dijo, bloating, biliary colic, sebete ho thatafala ha sebete, ho tsoa mali ho tswa ho pampitšana e sa tšoaneng GI;
• kopanetsoeng bohloko, mesifa spasm;
• malaise, ntaramane-joaloka lefu, feberu, chills, edema pheriferale, asthenia.

Litsenyehelo tsa ho sebelisa lithethefatsi, analogs le ulasan pelanggan

Ke bokae meriana ena e le "Ademethionine"? Theko ea sehlahisoa sena ke ka 1.500 li-ruble ka foromo Letlapa le ka bo-1900 li-ruble ka ente.

ho tlaleha moriana o ka nkeloa sebaka ha a lakatsa ka joalo e le "acid e Glutamic" "Karnith" "Histidine" "carnitine", "Epilapton", "Elkar".

Seo batho ba se buang mabapi le basebelisi ba lithethefatsi? Ho ea ka litlaleho tsa bakuli ba 'nile ba lefu sebete lithethefatsi "Ademethionine" ke eona feela ea sebele sebetsa gepatoprotektor. Bakuli ba nang le phumano ea "ho thatafala ha sebete" pheha khang ea hore sephetho molemo ka ho fetisisa kalafo ka finyelloang ha feela lithethefatsi a sebetsang a nkiloe makhetlo a 2 ka selemo 3-khoeli dithuto.

Ha e le lingaka tse hloahloa, ba ile ba tlaleha hore lithethefatsi "Ademethionine" ha a fane ka phatlalletsoang le ka potlako e le hantle e le mafu a hlabang sebeteng, lateloa ke stagnation ya bile ka lisele tsa 'mele.